Sökning: "copper chaperone"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden copper chaperone.

  1. 1. Human copper ion transfer : from metal chaperone to target transporter domain

    Författare :Moritz Sebastian Niemiec; Pernilla Wittung-Stafshede; Nigel Robinson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; copper homeostasis; copper chaperone; Atox1; ATP7B; Wilson disease protein; metal transport; size exclusion chromatography; thermodynamics; isothermal calorimetry;

    Sammanfattning : Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. LÄS MER

  3. 2. COPPER BINDING PROTEINS IN BREAST CANCER : CELLULAR AND MOLECULAR MECHANISMS

    Författare :Xiaolu Zhang; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atox1; Memo1; cell migration; breast cancer; copper; ROS;

    Sammanfattning : Cancer is one of the leading causes of human death. However, the mechanisms governing cancer are still not fully understood. Elevated levels of copper (Cu) have been observed in both cancerous tissues and the serum of cancer patients. LÄS MER

  4. 3. Assembly and Function of Nitric Oxide Reductase from Paracoccus denitrificans

    Författare :Maximilian Kahle; Pia Ädelroth; Hans-Georg Koch; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; non-heme iron; cofactor; heme-copper oxidase; AAA ; cNOR; chaperone; metal ion insertion; MoxR; nor accessory genes; FeB; liposomes; membrane mimetics; nanodiscs; reconstitution; enzymatic mechanism; NO reduction; O2 reduction; Biochemistry; biokemi;

    Sammanfattning : Bacterial denitrification is a part of the global nitrogen cycle and comprises the stepwise reduction of nitrate to molecular nitrogen, which is released to the atmosphere. Cytochrome c-dependent nitric oxide reductase (cNOR) from Paracoccus (P.) denitrificans catalyzes the reduction of nitric oxide to nitrous oxide and water. LÄS MER

  5. 4. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Författare :Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Sammanfattning :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER

  7. 5. Development of a Yeast Model for Functional Analysis of Human Copper Transport Proteins

    Författare :Kumaravel Ponnandai Schanmugavel; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; luminal loop; metal binding domains; Wilson’s disease protein; yeast model; ATP7B; copper transport.;

    Sammanfattning : ABSTRACT Copper (Cu) is an important trace element that plays a vital role in several biological processes. It mediates numerous biochemical functions to maintain cellular homeostasis making it an essential metal for sustaining life. LÄS MER