Sökning: "confirmatory trials"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden confirmatory trials.

  1. 1. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development

    Författare :Anne-Gaëlle Dosne; Mats O. Karlsson; Rik Schoemaker; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; confirmatory trials; residual error modeling; parameter uncertainty; sampling importance resampling; model-averaging; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. LÄS MER

  3. 2. A contribution to the design and analysis of phase III clinical trials

    Författare :Vera Lisovskaja; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Clinical trials are an established methodology for evaluation of the effects of a new medical treatment. These trials are usually divided into several phases, namely phase I through IV. The earlier phases (I and II) are relatively small and have a more exploratory nature. LÄS MER

  4. 3. Depression in teenagers and young adults : foundational studies of the new treatment paradigm TARA: Training for Awareness, Resilience, and Action

    Författare :Erik Ekbäck; Eva Henje Blom; Ida Blomqvist; Jenny Molin; Inga Dennhag; Thorbjörn Lundberg; Elizabeth McCauley; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; adolescents; young adults; medical students; mental health; anxiety; psychological stress; qualitative research; randomization; yoga; mindfulness; psychotherapy; antidepressant drugs; biomarkers; clinical trial; feasibility studies; online intervention; reliability; validity; confirmatory factor analysis; measurement invariance; barn- och ungdomspsykiatri; Child and Youth Psychiatry;

    Sammanfattning : Introduction: Depression in adolescents and young adults is an increasing global health concern and available treatments are not convincingly effective. It is therefore important to develop and test novel treatments to improve treatment outcomes. LÄS MER

  5. 4. Confirmation Bias in Criminal Cases

    Författare :Moa Lidén; Minna Gräns; Peter Juslin; Steven Penrod; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; legal decision making; bias; confirmation bias; criminal cases; criminal procedure; police; prosecutor; judge; legal system; empirical legal research; evidence based law; debiasing technique; Jurisprudence; Allmän rättslära;

    Sammanfattning : Confirmation bias is a tendency to selectively search for and emphasize information that is consistent with a preferred hypothesis, whereas opposing information is ignored or downgraded. This thesis examines the role of confirmation bias in criminal cases, primarily focusing on the Swedish legal setting. LÄS MER

  7. 5. Socioeconomic status and myocardial infarction : influence on secondary prevention and prognosis

    Författare :Joel Ohm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background and Aims: In the wealth of research undertaken on myocardial infarctions (MIs), secondary prevention is less well studied. Incidence and death from MI have declined substantially in the past decades due to the identification of cardiovascular (CV) risk factors, methods to assess risk in the general population, development of efficient therapies that modify risk factor levels, and the introduction of revascularization therapies used in the acute phase of a MI. LÄS MER