Sökning: "blood-brain barri-er BBB"

Hittade 1 avhandling innehållade orden blood-brain barri-er BBB.

1. 1. Design, expression, and analysis of antibody-based blood-brain barrier shuttles

   Författare :Andrés de la Rosa; Greta Hultqvist; Paul O'Callaghan; Nicole G. Metzendorf; Torben Moos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody therapeutics; transient gene expression; protein production; blood-brain barri-er BBB ; BBB shuttle; brain delivery; Transferrin receptor TfR ; heparan sulfate; holo-transferrin; Molekylär biovetenskap; Molecular Life Sciences;

   Sammanfattning : Antibody therapeutics, with their strong and highly selective target binding, are now used to treat various diseases. However, to enable their use to treat brain disorders, they must be delivered across the blood-brain barrier (BBB), as without active transport, only around 0.01% of intravenously injected doses reach the brain. LÄS MER