Sökning: "beta cell"

Visar resultat 21 - 25 av 670 avhandlingar innehållade orden beta cell.

1. 21. Studies of sulfatide expression in relation to beta cell function

   Författare :Maria K. Blomqvist; Göteborgs universitet; []
   Nyckelord :sulfatide; glycosphingolipid; insulin; beta cell; diabetes mellitus; animal models; ; beta cell line;

   Sammanfattning : Previous studies have shown that the glycosphingolipid sulfatide (3´-sulfogalactosyl-ceramide) is present and functionally involved in pancreatic beta cells. In these cells, sulfatide is synthesised as two major isoforms, C16:0 and C24:0 sulfatide, with different length of the fatty acid chain of the ceramide moiety. LÄS MER

3. 22. Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems

   Författare :Jakob Domert; Martin Hallbeck; Jan Marcusson; Lars Tjernberg; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-to-cell transfer; beta-amyloid; Alzheimer s disease; degradation; proteasome; alpha-synuclein; Parkinson s disease; high throughput screening model;

   Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are defined by neurodegeneration and accumulations of misfolded proteins that spread through the brain in a well characterized manner. In AD these accumulations consist mainly of β-amyloid (Aβ) and tau, while in PD, α-synuclein (α-syn) make up the characteristic lewy pathology. LÄS MER

4. 23. Expression and Regulation of Neuropeptide Y (NPY) in the Islets of Langerhans

   Författare :Ulrika Myrsén Axcrona; Neuroendokrin cellbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; regulatory peptides; diabetes; glucocorticoids; beta cell; islet hormones; neuropeptide Y; insulin; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : This thesis deals with the expression, localization and regulation of neuropeptide Y (NPY) in the pancreatic islets of Langerhans under normal and experimental conditions. NPY is widely distributed in the mammalian nervous system and belongs to a family of closely related petides also comprising peptide YY (PYY) and pancreatic polypeptide (PP). LÄS MER

5. 24. Study of the Proliferation, Function and Death of Insulin-Producing Beta-Cells in vitro: Role of the Transcription Factor ZBED6

   Författare :Xuan Wang; Nils Welsh; Nils Billestrup; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; Pancreatic beta-cell; Proliferation; Insulin secretion; Apoptosis; Adhesion; Medical Science; Medicinsk vetenskap;

   Sammanfattning : A thorough understanding of beta-cell proliferation, function, death and regeneration under normal condition as well as in the progression of diabetes is crucial to the conquest of this disease. The work presented in this thesis aimed to investigate the expression and role of a novel transcription factor, Zinc finger BED domain-containing protein 6 (ZBED6), in beta-cells. LÄS MER

7. 25. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function

   Författare :Magdalena Mazur; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas development; beta cells; insulin; MafA; MafB; Mitf; diabetes;

   Sammanfattning : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. LÄS MER