Sökning: "islet hormones"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden islet hormones.

1. 1. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease

   Författare :Sara Ullsten; Per-Ola Carlsson; Joey Lau; Sara Bohman; Rebecca L. Hull; Uppsala universitet; []
   Nyckelord :Pancreatic islets; heterogeneity; islet vascularity; blood flow; islet transplantation; islet amyloid; insulitis; type 1 diabetes; beta cell proliferation; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. LÄS MER

3. 2. On Meal Effects and DPP-4 Inhibition Islet- and Incretin Hormones in Health and Type 2 Diabetes

   Författare :Wathik Alsalim; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; Healthy subjects; Meal composition; Incretin hormones; DPP-4 inhibition;

   Sammanfattning : .... LÄS MER

4. 3. Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans

   Författare :Samuel Acreman; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet; diabetes; glucagon; insulin; somatostatin; incretin; pancreas; hypoglycaemia; tetraspanin; GLP-1; endoplasmic reticulum;

   Sammanfattning : Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon secretion, independent of membrane potential, from pancreatic α-cells, via modulation of endoplasmic reticulum Ca2+ handling. LÄS MER

5. 4. Childhood Obesity and Islet Function

   Författare :Johan Staaf; Peter Bergsten; Anders Forslund; Hindrik Mulder; Uppsala universitet; []
   Nyckelord :type 2 diabetes mellitus; Uppsala Longitudinal Study of Childhood Obesity; palmitate; glucose-stimulated insulin secretion; hyperinsulinemia; hyperglucagonemia; GLP-1; glicentin; magnetic resonance imaging; metabolic syndrome; oral glucose tolerance test; centroid; Pediatrik; Pediatrics;

   Sammanfattning : The prevalence of childhood obesity and Type 2 Diabetes Mellitus (T2DM) has increased during recent decades. T2DM is accompanied with functional changes in the islets of Langerhans, which can be identified early in the pathogenesis. LÄS MER

7. 5. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

   Författare :Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

   Sammanfattning : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. LÄS MER