Sökning: "Tumor suppressor gene TSG"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Tumor suppressor gene TSG.

  1. 1. Development of new approaches for tumor suppressor genes identification

    Författare :Jinfeng Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor suppressor gene TSG ; Cloning of deleted sequences CODE ; Cloning of polymorphisms COP ; Cloning of identical sequences CIS ; Gene inactivation test GIT .;

    Sammanfattning : Development of tumor is a complex process involving multiple steps. New technologies for cloning and identifying genes playing critical role in cancer development are necessary. That is why we have focused our research on development of these approaches. LÄS MER

  3. 2. Identification of tumor suppressor genes using the approach of gene inactivation test

    Författare :Fuli Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial cancers are the most prevalent and lethal diseases in the world. They cause more than 80% of all cancer deaths. Development of these tumors is a complex process involving more than 100 genes from different chromosomes. We know that human chromosome 3 (chr. LÄS MER

  4. 3. The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer

    Författare :Shahab Akhoondi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various human tumor types and explored alternative mechanism(s) for the inactivation of FBW7. LÄS MER

  5. 4. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

    Författare :Jian Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

    Sammanfattning : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. LÄS MER

  7. 5. Mutational analyses of the tumor suppressor gene Patched1 : role in non-melanoma skin cancer and nevoid basal cell carcinoma

    Författare :Erika Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skin cancer is the most common cancer in Western countries, with a rapidly increasing incidence. The majority of these tumors are non-melanoma skin cancer (NMSC). The most common NMSC is basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC). In the US more than 1. LÄS MER