Sökning: "TIMP-1"

Visar resultat 16 - 20 av 45 avhandlingar innehållade ordet TIMP-1.

  1. 16. Inflammation and cortisol response in coronary artery disease

    Författare :Johnny Nijm; Lena Jonasson; Eva Särendahl; Per Tornvall; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coronary artery disease; Cardiology; Kardiologi; Internal medicine; Invärtesmedicin;

    Sammanfattning : Atherosclerosis is characterized by a chronic inflammation, involving autoimmune components, in the arterial wall. An increase in proinflammatory activity relative to anti-inflammatory activity is considered to cause a progression of the disease towards plaque instability and risk of atherothrombotic events, such as acute coronary syndrome (ACS). LÄS MER

  3. 17. Systemic sclerosis : vascular, pulmonary and immunological aspects

    Författare :Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

    Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER

  4. 18. Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications

    Författare :Joman Javadi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple diagnostic tools, is challenging and treatment options are limited. LÄS MER

  5. 19. Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity

    Författare :Simon Jönsson; Lena Jonasson; Anna Lundberg; Magnus Bäck; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inflammation is closely associated with development of atherosclerosis. The proteolytic enzyme matrix metalloproteinase (MMP)-9 is considered to play a prominent role in this process. MMP-9 has also been introduced as a marker for plaque vulnerability. LÄS MER

  7. 20. Treatment of subacromial pain and rotator cuff tears

    Författare :Hanna Cecilia Björnsson Hallgren; Lars Adolfsson; Kajsa Johansson; Rolf Norlin; Li Tsai-Fällender; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Shoulder; rotator cuff tear; ultrasound; surgery; exercises;

    Sammanfattning : Shoulder pain is very common, affecting 14-21 % of the population at some time during their lifetime. The aims of this thesis were to improve the understanding of various aspects concerning the pathogenesis and treatment of subacromial pain and rotator cuff tears. LÄS MER