Sökning: "Sven P. Jacobsson"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Sven P. Jacobsson.

  1. 1. Cold trapping and reinjection techniques for gas chromatography-mass spectrometry

    Författare :Sven P. Jacobsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis describes the use of cold trapping and reinjection techniques in combination with gas chromatography-mass spectrometry. A summary of different cold trap/ reinjection systems is presented. LÄS MER

  3. 2. Processing and analysis of NMR data : Impurity determination and metabolic profiling

    Författare :Jenny Forshed; Sven P. Jacobsson; Jules L. Griffin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; quantitative nuclear magnetic resonance spectrometry; qNMR; multivariate analysis; peak alignment; data fusion; Analytical chemistry; Analytisk kemi;

    Sammanfattning : This thesis describes the use of nuclear magnetic resonance (NMR) spectrometry as an analytical tool. The theory of NMR spectroscopy in general and quantitative NMR spectrometry (qNMR) in particular is described and the instrumental properties and parameter setups for qNMR measurements are discussed. LÄS MER

  4. 3. Aspects of Optimisation of Separation of Drugs by Chemometrics

    Författare :Valérie Harang; Douglas Westerlund; Sven P. Jacobsson; Bo Karlberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; optimisation; separation; chemometrics; high performance liquid chromatography; electrodriven techniques; microemulsion electrokinetic chromatography; statistical experimental design; molecular modelling; chiral separation; cellobiohydrolase; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Statistical experimental designs have been used for method development and optimisation of separation. Two reversed phase HPLC methods were optimised. LÄS MER

  5. 4. Novel on-line mid infrared detection strategies in capillary electrophoretic systems

    Författare :Malin Kölhed; Bo Karlberg; Sven P. Jacobsson; Andre' J. Sommer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; on-line hyphenation; mid infrared detection; capillary electrophoresis; FTIR; quantum cascade laser; aqueous samples; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Infrared absorption spectra can provide analytically useful information on a large variety of compounds, ranging from small ions to large biological molecules. In fact, all analytes that possess a dipole moment that changes during vibration are infrared-active. The infrared (IR) spectrum can be subdivided into far-, mid- and near- regions. LÄS MER

  7. 5. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

    Författare :Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. LÄS MER