Sökning: "SUVmax"

Hittade 5 avhandlingar innehållade ordet SUVmax.

  1. 1. Pharmacometrics to improve clinical benefit assessment in oncology

    Författare :Emilie Schindler; Lena E Friberg; Mats O Karlsson; Rik de Greef; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacokinetics; pharmacodynamics; VEGF; SLD; targeted therapies; IRT; FDG-PET; SUVmax; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival (OS), and patient-reported outcomes (PROs). LÄS MER

  3. 2. Pituitary Tumors - Epidemiology and the Diagnostic Value of 68Ga-DOTATOC PET

    Författare :Axel Tjörnstrand; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; Pituitary neuroendocrine tumor; pituitary tumor; somatostatin receptor imaging; gallium68; 68Ga; SSTR; SSTR-PET;

    Sammanfattning : Pituitary neuroendocrine tumors (PitNETs) are considered common in the general population. However benign in most cases, these tumors can evoke dramatic morbidity in patients with aggressive tumor growth and/or excess hormone secretion. LÄS MER

  4. 3. Differentiation of renal oncocytoma from renal cell carcinoma by means of ⁹⁹Tc-Sestamibi SPECT/CT

    Författare :Antonios Tzortzakakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Purpose: An increasing body of literature indicates the beneficial role of [99m]Tc-Sestamibi SPECT/CT in the non-invasive differentiation of renal oncocytoma (RO) from renal cell carcinoma (RCC). This thesis presents a comprehensive approach of [99m]Tc-Sestamibi SPECT/CT examination following the implementation of quantitative tools in addition to visual assessment. LÄS MER

  5. 4. Improved adrenocortical PET imaging

    Författare :Isabella Silins; Peter Stålberg; Per Hellman; Gunnar Antoni; Anders Sundin; Azita Monazzam; Håkan Geijer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Introduction: Adrenal tumours can either be benign or malignant, hormone secreting or not, and they can be discovered through clinical examination of the patient or by pure chance. Increased knowledge in the area, plus the widespread use of imaging techniques, have resulted in a rising number of patients with adrenal tumours that subsequently need to be diagnosed. LÄS MER

  7. 5. PET/CT with 18F-FDG and 68Ga-DOTATOC in pulmonary carcinoid imaging

    Författare :Natalja Uhlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: PET/CT, positron emission tomography combined with computed tomography, with 18F-FDG (2-deoxy-2-[18F]fluoro-D-glucose) is well established in oncological imaging. Pulmonary carcinoid tumours may have metabolic activity, making them available for PET/CT imaging with 18F-FDG. LÄS MER