Sökning: "Pediatric CNS tumors"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Pediatric CNS tumors.

  1. 1. Brain tumors in children - National population-based studies on classification, diagnostics and long-term follow-up

    Författare :Elizabeth Schepke; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric CNS tumors; population-based; DNA methylation; profiling; CNS-PNET; re-evaluation; incidence rate; long-term outcome; classification; Pediatric CNS tumors; Population-based; DNA methylation; Profiling; CNS-PNET; Re-evaluation; Incidence rate; Long-term outcome; Classification;

    Sammanfattning : Although the prognosis for pediatric tumors of the central nervous system (CNS) has improved over time it is urgent to reduce mortality and improve long-term quality of life for survivors. With this aim, the first step is to identify the correct diagnosis in order to choose the right therapy and avoid unnecessary treatment. LÄS MER

  3. 2. HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?

    Författare :Atosa Estekizadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented in several cancer types. LÄS MER

  4. 3. Liquid biopsies in pediatric oncology : towards clinical implementation

    Författare :Cecilia Arthur; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies could serve many purposes in childhood oncology as well. LÄS MER

  5. 4. Microglia in the juvenile brain after cranial irradiation

    Författare :Kai Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Radiotherapy is used to treat pediatric brain tumors and is often accompanied with debilitating late effects, such as cognitive decline. However, the mechanisms are poorly understood, and consequently there is still no effective treatment. LÄS MER

  7. 5. Wnt signaling in early brain development and disease

    Författare :Panagiotis Papachristou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Wnt/Planar Cell Polarity (PCP) signaling is involved in many cellular processes throughout the development of the embryo. These include control of proliferation, differentiation, migration and cell fate decisions. Deregulation of Wnt/PCP signaling can lead to many developmental abnormalities and cancer. LÄS MER