Sökning: "Neuroendocrine tumour"

Visar resultat 6 - 10 av 28 avhandlingar innehållade orden Neuroendocrine tumour.

  1. 6. Small Intestinal Neuroendocrine Tumours : Genetic and Epigenetic Studies and Novel Serum Biomarkers

    Författare :Katarina Edfeldt; Peter Stålberg; Per Hellman; Gunnar Westin; Malin Sund; Endokrinkirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SI-NET; microarray; tumour suppressor gene; epigenetic; serum biomarkers; Kirurgi; Surgery;

    Sammanfattning : Small intestinal neuroendocrine tumours (SI-NETs) are rare, hormone producing and proliferate slowly. Patients usually display metastases at time of diagnosis, the tumours are difficult to cure, and the disease course is unpredictable. LÄS MER

  3. 7. Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies

    Författare :Anna-Karin Elf; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumour; peptide receptor radionuclide therapy; somatostatin receptor 2 expression; radiosensitization; radioembolization; diffusion weighted imaging;

    Sammanfattning : ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. LÄS MER

  4. 8. Tumour Biological Factors Characterizing Metastasizing Serotonin-producing Ileocaecal Carcinoids

    Författare :Janet Lynn Cunningham; Eva Tiensuu Janson; Kjell Öberg; Irvin M. Modlin; Uppsala universitet; []
    Nyckelord :Internal medicine; endocrine tumour; midgut carcinoid; serotonin-producing neuroendocrine carcinoma; prognosis; morphology; tachykinin; connective tissue growth factor; islet autoantigen-2; morphology; carcinoid syndrome; Invärtesmedicin;

    Sammanfattning : In this study, metastasizing serotonin-producing ileocaecal carcinoid tumours (MSPCs) were examined for biological characteristics that could be used to define clinically relevant subgroups within this patient population. Possible targets for new treatment options were also explored. LÄS MER

  5. 9. Vesicle proteins as markers for neuroendocrine tumors

    Författare :Anne-Marie Levin Jakobsen; Göteborgs universitet; []
    Nyckelord :Neuroendocrine tumours; gastrointestinal tract; pancreas; adrenal; vesicle proteins; ; SV2; NESP55; VMAT1; VMAT2; MIBG;

    Sammanfattning : The neuroendocrine (NE) tumours comprise a diversity of tumours which share commonproperties, e.g. the capacity to produce, store and release hormones. A prominent feature ofthe NE phenotype is the production of secretory granules with associated vescicle proteins,e. LÄS MER

  7. 10. Pharmacokinetics and dosimetry of radiolabelled octreotide for tumour therapy

    Författare :Peter Bernhardt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; radiation dosimetry; therapy; radionuclides; octreotide; neuroendocrine tumours; nude mice; patients;

    Sammanfattning : Somatostatin (SS) receptors (sstr) are usually highly expressed on neuroendocrine (NE) tumours. The radiolabelled SS analogue 111In-DTPA-D-Phe1-octreotide is today widely used to scintigraphically visualise NE tumours, and high 111In activity concentrations are obtained in tumour vs. normal tissues. LÄS MER