Sökning: "NF-kB"

Visar resultat 6 - 10 av 50 avhandlingar innehållade ordet NF-kB.

  1. 6. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action

    Författare :Manuela Terrinoni; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vaccine development; plasmid maintenance; Gram-negative bacteria; ; essential genes; complementation; Cholera Toxin; adjuvanticity; NF-kB; mmCT; Gram-negative bacteria;

    Sammanfattning : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. LÄS MER

  3. 7. Role of POU/Oct transcription factors in Drosophila immunity

    Författare :Widad Dantoft; Ylva Engström; Anne Uv; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antimicrobial peptides; Drosophila; host-pathogen interaction; immune gene expression; immune signaling; NF-kB; microbiota; POU Oct transcription factors; protein degradation; stress response; transcriptional regulation; Molecular Biology; molekylärbiologi;

    Sammanfattning : In response to infection, Drosophila melanogaster relies on the ability to mount a robust and potent innate immune response, characterized by induction of cellular and humoral processes. While rapid immune induction is of utmost importance, it is equally important to restrict and repress immune gene expression, where and when it is not needed. LÄS MER

  4. 8. Arthritogenic property of bacterial DNA containing CpG motifs

    Författare :Guo-Min Deng; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacterial DNA; CpG ODN; arthritis; macrophage; lymphocytes; TNFa; NF-kB; mice;

    Sammanfattning : .... LÄS MER

  5. 9. Functional study of Nucleoporins Nup88 and Nup214 during Drosophila Development

    Författare :Nikos Xylourgidis; Christos Samakovlis; Valerie Doye; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mbo; Nup88; CAN; Nup214; NPC; CRM1; embargoed; NF-kB; REL; Dorsal; Dif; Drosophila; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : More than a million macromolecules per minute pass through the nuclear envelope of a eukaryotic cell. An important challenge is to understand how the NPC coordinate efficiently the bi-directional trafficking necessary for the basal cellular activities and the rapid translocation of regulatory proteins in response to signaling. LÄS MER

  7. 10. Regulation of antimicrobial peptide gene expression in Drosophila melanogaster : Involvement of POU and NF-kB/Rel factors in innate immunity

    Författare :Anna Junell; Ylva Engström; Jean-Luc Imler; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The fruit fly, Drosophila melanogaster, has a well-developed immune response, and microbial assault induces a rapid production of potent antimicrobial peptides (AMPs). The aim of this thesis work was to gain deeper knowledge of the regulation of AMPs in Drosophila, by the isolation and characterization of transcription factors involved in AMP gene expression. LÄS MER