Sökning: "TNFa"

Visar resultat 1 - 5 av 32 avhandlingar innehållade ordet TNFa.

  1. 1. Arthritogenic property of bacterial DNA containing CpG motifs

    Författare :Guo-Min Deng; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacterial DNA; CpG ODN; arthritis; macrophage; lymphocytes; TNFa; NF-kB; mice;

    Sammanfattning : .... LÄS MER

  3. 2. Vascular and metabolic effects of selective PDE-5 inhibition - clinical and experimental studies

    Författare :Lovisa Sjögren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; MAPK; phosphodiesterase-5 inhibition; JNK; endothelial cells; E-selectine; VCAM-1; HUVEC; TNFa; ICAM-1; inflammation;

    Sammanfattning : ABSTRACT Vascular and metabolic effects of selective PDE-5 inhibition Clinical and experimental studies Lovisa Sjögren Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg Key words: Type 2 diabetes, phosphodiesterase-5 inhibition, inflammation, endothelial cells, HUVEC. TNFα, ICAM-1, VCAM-1, E-Selectin, JNK, MAPK Background: Type 2 diabetes (T2D) patients show impaired glucose metabolism, endothelial dysfunction, chronic low-grade inflammation as well as an increased risk of cardiovascular disease. LÄS MER

  4. 3. Immunopathology of Inflammatory Bowel Disease

    Författare :Mohammad Kadivar; Leukocyt migration; []
    Nyckelord :Inflammatory bowel disease IBD ; Crohn s disease; Ulcerative colitis; T cell; Monocyte; macrophage; Neutrophil; anti-TNFa treatment; IBD disease activity index;

    Sammanfattning : Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract, with a remitting and relapsing course. There are two main forms of IBD: Crohn’s disease (CD) and ulcerative colitis (UC). LÄS MER

  5. 4. Immunogenetic markers in immune mediated diseases

    Författare :Liene Nikitina-Zake; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HLA; MICA; TNFA; TNFa; KIR; CIN; cervical cancer; juvenile arthritis; MCTD; type I diabetes mellitus;

    Sammanfattning : The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile idiopathic arthritis (JIA), mixed connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM). HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune-mediated diseases due to the function of the molecules these genes encode. LÄS MER

  7. 5. Cytokine regulation in rodents with experimental arthritis

    Författare :Åsa Boström Müssener; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :collagen-induced arthritis; oil-induced arthritis; IL-2; IL-4; TNFa; IFNy; TGFß;

    Sammanfattning : The general aim of this project has been to try to elucidate the mechanisms behind induction of arthritis by using in situ hybridization and immunohistochemical methods to analyse the dynamics of the cytokine network in vivo, in the peripheral Iymphoid system and in the joints of rodents with collagen-induced arthritis (CIA)and oil-induced arthritis (OIA). We first examined the kinetics of cytokine gene expression in vivo, in the draining Iymph nodes of DA rats following immunization with rat type II collagen (RCII) emulsified in Freund's incomplete adjuvant oil (FIA) or with only FIA, which are regimens that induce CIA and OIA, respectively. LÄS MER