Sökning: "NATURVETENSKAP Kemi Teoretisk kemi Bioinformatik"

Visar resultat 11 - 15 av 16 avhandlingar innehållade orden NATURVETENSKAP Kemi Teoretisk kemi Bioinformatik.

1. 11. Network and gene expression analyses for understanding protein function

   Författare :Oliver Frings; Erik Sonnhammer; Rune Linding; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; network inference; network analysis; clustering; network module; network crosstalk; expression analysis; gene signature; biomarker; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Biological function is the result of a complex network of functional associations between genes or their products. Modeling the dynamics underlying biological networks is one of the big challenges in bioinformatics. LÄS MER

3. 12. The relationship between orthology, protein domain architecture and protein function

   Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER

4. 13. Biological data exchange and the discovery of new protein families in metagenomic samples

   Författare :David N. Messina; Erik Sonnhammer; Miguel Andrade; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : The rise in sequence data has brought both challenges to the way we exchange biological information and opportunities to discover new protein families, primarily through the investigation of uncultured metagenomic samples.The Distributed Annotation System, or DAS, provided a means for exchanging protein sequence data, but there were no open source, stand-alone DAS clients optimized for integrating and viewing these data. LÄS MER

5. 14. Inference of functional association networks and gene orthology

   Författare :Thomas Schmitt; Erik L. L. Sonnhammer; Søren Brunak; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; orthology; InParanoid; FunCoup; systems biology; biological networks; network inference; functional coupling; functional association; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. LÄS MER

7. 15. Ensemble methods for protein structure prediction

   Författare :Marcin J. Skwark; Arne Elofsson; Michael Tress; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; model quality assessment; contact prediction; homology modeling; ab-initio prediction; consensus prediction; structural bioinformatics; bioinformatics; protein structure; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Proteins play an essential role in virtually all of life's processes. Their function is tightly coupled to the three-dimensional structure they adopt.Solving protein structures experimentally is a complicated, time- and resource-consuming endeavor. LÄS MER