Sökning: "HSAN V"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden HSAN V.

  1. 1. Genetics of pain : studies of migraine and pain insensitivity

    Författare :Anna Norberg; Monica Holmberg; Arn van den Maagdenberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Migraine; pain insensitivity; susceptibility genes; genome-wide scan; linkage; polymorphism; association; HSAN V; nerve growth factor; neurite outgrowth; Medical genetics; Medicinsk genetik;

    Sammanfattning : Pain is a major public health issue throughout the world. Increased understanding of the different forms of pain and identification of susceptibility genes could contribute to improved treatments. LÄS MER

  3. 2. Norrbottnian congenital insensitivity to pain

    Författare :Jan Minde; Göran Toolanen; Li Tsai-Fällender; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain insensitivity; HSAN; Orthopaedics; Ortopedi;

    Sammanfattning : Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor β gene (NGFß). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11. LÄS MER

  4. 3. A pathway for pleasant touch: linking peripheral receptors to central processing and hedonic experience

    Författare :Line Sofie Löken; Göteborgs universitet; []
    Nyckelord :pleasant; touch; microneurography; human; CT afferent; unmyelinated;

    Sammanfattning : This thesis investigates the mechanisms underpinning pleasant touch, describes a pathway from peripheral nerve endings in the skin to the insular cortex, and relates these findings to the subjective hedonic experience of touch. In Paper I, the relationship between primary afferent encoding and perception of pleasantness was investigated by combining microneurography recordings from human mechanoreceptors with psychophysical measurements during soft brush stroking at 6 different velocities between 0. LÄS MER

  5. 4. Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures

    Författare :Kristina Ängeby Möller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently there are few treatments available. LÄS MER

  7. 5. Drug discovery targeting non-amyloid pathways in Alzheimer’s disease

    Författare :Märta Dahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available. In the hereditary forms of AD, an overproduction of amyloid β (Aβ) and the Aβ plaque formation are the basis for the amyloid hypothesis of AD, while several additional factors seem to influence the likelihood to develop sporadic forms of AD. LÄS MER