Sökning: "FGFs"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet FGFs.

  1. 1. FGFs and Wnts in pancreatic growth and β-cell function

    Författare :Stella Papadopoulou; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Wnt; FGF; pancreas; Notch; signal transduction; development; proliferation; progenitors; β-cells; feedback; GSIS; diabetes; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Mesenchymal-epithelial interactions are pivotal for proper pancreatic growth and development. The pancreatic progenitor cells present in the early pancreatic anlagen proliferate and eventually give rise to all pancreatic cell types. LÄS MER

  3. 2. Modern inhalation agents and effects of anaesthesia equipment during low-flow anaesthesia

    Författare :Anders Johansson; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anestesiologi; intensive care; intensivvård; Anaesthesiology; humidity and temperature; heat and moisture exchanger; isoflurane; desflurane; sevoflurane; anaesthetics volatile; carbon dioxide absorber; Low-flow; re-breathing circle circuit;

    Sammanfattning : Volatile agents are economically and ecologically acceptable only when administered via low-flow systems. However, sevoflurane degrades during low-flow anaesthesia to compound A, and a high carbon dioxide absorber temperature increases this degradation. LÄS MER

  4. 3. Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction

    Författare :Lars Lundin; Lena Claesson-Welsh; Marco Presta; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR; dimerisation; signal transduction; heparan sulfate; proteoglycan; heparin; VEGF; embryonal stem cell; endothelial cell; differentiation; Patologi; Pathology; Patologi;

    Sammanfattning : Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. LÄS MER

  5. 4. Role of Heparan Sulfate Structure in FGF-Receptor Interactions and Signaling

    Författare :Nadja Jastrebova; Dorothe Spillmann; Ulf Lindahl; John T. Gallagher; Uppsala universitet; []
    Nyckelord :Biochemistry; heparan sulfate; oligosaccharide; fibroblast growth factor; fibroblast growth factor signaling; Biokemi;

    Sammanfattning : Heparan sulfate (HS) belongs to the glycosaminoglycan family of polysaccharides and is found attached to protein cores on cell surfaces and in the extracellular matrix. The HS backbone consists of alternating hexuronic acid and glucosamine units and undergoes a number of modification reactions creating HS chains with alternating highly and low modified domains, where high degree of modification correlates with high negative charge. LÄS MER

  7. 5. Gene expression in human adipose tissue. Studies of leptin and genes selected by expression profiling

    Författare :Britt Gabrielsson; Göteborgs universitet; []
    Nyckelord :obesity; subcutaneous; omental; DNA microarray; sulfonylurea receptor; fibroblast; growth factors; complement system; fibroblast;

    Sammanfattning : Obesity, and in particular the amount of visceral adipose tissue, is correlated to development of type 2diabetes and cardiovascular disease. The aim of this thesis was to study genes expressed in humanadipose tissue that could be involved in regional adipose tissue homeostasis and/or obesity-associateddisease. LÄS MER