Sökning: "Clofazimine"

Hittade 3 avhandlingar innehållade ordet Clofazimine.

1. 1. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

   Författare :Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. LÄS MER

3. 2. Computational and chemical approaches to drug repurposing

   Författare :Xuexin Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two primary approaches: computational and chemical. LÄS MER

4. 3. Drug resistance in mycobacterium tuberculosis

   Författare :Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

   Sammanfattning : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. LÄS MER