Sökning: "Calpain"

Visar resultat 21 - 25 av 40 avhandlingar innehållade ordet Calpain.

  1. 21. Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs

    Författare :Anne Kling-Petersen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidation NSAIDs ASA dexamethasone apoptosis GSH GSSG proteasome lens epithelial cells mouse lens cataract;

    Sammanfattning : Oxidative stress has been implied in formation of age-related cataract. The objectives of this thesis were to study redox regulation of proteolysis and oxidative/antioxidative effects of anti-inflammatory substances in human lens epithelial cells (HLEC) and intact mouse lenses. LÄS MER

  3. 22. Mitochondrial involvement in cell death : release of pro-apoptotic proteins

    Författare :Erik Norberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In addition to the role of the mitochondria in energy metabolism, these organelles play a key role in cell death signaling. In particular, mitochondrial alterations, such as stimulation of reactive oxygen species (ROS) formation, decreased ATP synthesis, loss of membrane potential and the release of pro-apoptotic proteins from the mitochondrial intermembrane space (IMS), have been shown to be involved in, and often responsible for, various manifestations of cell death. LÄS MER

  4. 23. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Författare :Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. LÄS MER

  5. 24. Mechanisms and time course of cell death in embryonic nigral tissue and intrastriatal transplants

    Författare :Mia Emgård; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothermia; resveratrol; free radicals; ultrastructure; electron microscopy; mesencephalic; transplantation; rat; Parkinson s disease; dopamine; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and severely affects about one in a hundred persons over the age of fifty years. In PD, there is a reduced striatal concentration of the neurotransmittor dopamine, mainly caused by a degeneration of the dopaminergic neurons in the substantia nigra. LÄS MER

  7. 25. A molecular characterization of selected cecropins and cysteine proteinases in Drosophila

    Författare :Ylva Tryselius; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Insects that have been infected with bacteria produce antibacterial peptides. Among the most potent antibacterial peptides in Drosophila are the cecropins. This work describes the cloning and expression studies of the CecC gene, which completes the picture of the cecropin locus in Drosophila melanogaster. LÄS MER