Sökning: "Calpain"

Visar resultat 6 - 10 av 40 avhandlingar innehållade ordet Calpain.

  1. 6. Genetic studies of diabetes in northern Sweden

    Författare :Sofia Mayans; Dan Holmberg; Mats Eliasson; Outi Vaarala; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; families; genetic; association; SNP; linkage; TCF7L2; CTLA-4; Calpain-10; Medical genetics; Medicinsk genetik;

    Sammanfattning : Diabetes mellitus represents a group of metabolic disorders caused by both environmental and genetic factors. The two most common forms of diabetes are type 2 diabetes (T2D) and type 1 diabetes (T1D). T2D is associated with obesity and the disease is caused by insulin resistance and pancreatic b-cell dysfunction. LÄS MER

  3. 7. Pathogenesis of type 2 diabetes -role of defects in insulin secretion and insulin sensitivity

    Författare :Devjit Tripathy; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; Calpain 10 gene; genetics of type 2 diabetes; MODY; Endogenous glucose production; Disposition index; Botnia clamp; IGT; IFG; HOMA; insulin sensitivity; insulin secretion;

    Sammanfattning : Type 2 diabetes is characterised by defects in insulin sensitivity, insulin secretion and increased endogenous glucose production. The relative contribution of each of these defects remains controversial. LÄS MER

  4. 8. Elucidation of pro-apoptotic signaling induced by cisplatin

    Författare :Aleksandra Mandic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Keywords: Cisplatin; apoptosis; signal transduction; Bak; calpain; endoplasmic reticulum;

    Sammanfattning : A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. LÄS MER

  5. 9. The IGF-IGFBP system in aerobic exercise : with focus on skeletal muscle

    Författare :Ulrika Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF-I; IGFBP-1; microdialysis; exercise; IL-6; calpain;

    Sammanfattning : Activity induced skeletal muscle adaptation has been suggested to be mediated largely by intrinsic factors, such as insulin-like growth factor (IGF)-I. IGF-I stimulates muscle glucose and amino acid uptake and promotes anabolism. LÄS MER

  7. 10. Molecular and functional studies of interleukin-1a in the rat testis

    Författare :Taranum Sultana; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Interleukin-l alpha; spermatogenesis; Leydig cells; Sertoli cells; calpain I and II;

    Sammanfattning : The aim of the present study was to gain a better insight into the role of interleukin-1 alpha (IL-1 alpha) in testicular physiology. In testis, IL-1alpha acts as a paracrine mediator involved in the regulation of testicular functions. LÄS MER