Sökning: "Björn Zethelius"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Björn Zethelius.

  1. 1. Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease : Clinical Epidemiological Studies with up to 27 Years of Follow-Up

    Författare :Björn Zethelius; Björn Fagerberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; diabetes; coronary heart disease; insulin; proinsulin; prognosis; mortality; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Geriatrics; geriatrik;

    Sammanfattning : Defects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules. LÄS MER

  3. 2. Measurement Variability Related to Insulin Secretion and Sensitivity : Assessment and Implications in Epidemiological Studies

    Författare :Lars Berglund; Björn Zethelius; Johan Bring; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Geriatrics; Geriatrik;

    Sammanfattning : There is a growing interest in random measurement variability of biological variables. In regression models, such variability of the predictors yields biased estimators of coefficients (regression dilution bias). LÄS MER

  4. 3. Independent Ageing in Very Old Swedish Men

    Författare :Kristin Franzon; Lena Kilander; Björn Zethelius; Tommy Cederholm; Jan Marcusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Independent ageing; survival; sarcopenia; comorbidity; body mass index; smoking; dietary pattern; dietary biomarkers; longitudinal; octogenarians; nonagenarians; Geriatrics; Geriatrik;

    Sammanfattning : Predictors for survival have been investigated thoroughly, but less is known about how to reach high age with preserved physical and cognitive function. These functions are crucial to stay independent in daily life, which is highly valued by the oldest old.This thesis was based on data from the Uppsala Longitudinal Study in Adult Men. LÄS MER

  5. 4. Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions

    Författare :Birgitta Grundmark; Lars Holmberg; Björn Zethelius; Gunnar Engström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Epidemiology; Pharmacoepidemiology; Metabolic Syndrome; Selenium; Smoking; hOGG1; MnSOD; Competing Risk; Adherence; Persistance; Medical Possession Ratio; MPR; Signal Detection; PRR; proportional reporting ratio; ULSAM; PcBaSE; EudraVigilance; SPDR; Swedish Prescribe Drug Registry; NPCR; National Prostate Cancer Registry; SDR; Signal; disproportionality analysis; PRR-TA; EudraVigilance; Epidemiology; Epidemiologi; Kirurgi; särskilt urologi; Urology; Oncology; Onkologi; Geriatrics; Geriatrik;

    Sammanfattning : Increased possibilities during the last decades for early detection of prostate cancer have sparked research on preventable or treatable risk factors and on improvements in therapy. Treatments of the disease still entail significant side effects potentially affecting men during the rest of their lives. LÄS MER

  7. 5. The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin

    Författare :Hans-Erik Johansson; Björn Zethelius; Arvo Hänni; Margareta Öhrvall; Lars Lannfelt; Claes-Göran Östenson; Uppsala universitet; []
    Nyckelord :Proinsulin; insulin; glucose; obesity; bariatric surgery; MEDICINE; MEDICIN;

    Sammanfattning : Hyperproinsulinemia is associated with type 2 diabetes (T2DM) and obesity and is a predictor for future coronary heart disease. This thesis examines the effect of bariatric surgery on glucometabolic status including insulin and proinsulin responses after meal. LÄS MER