Sökning: "Basic-Helix-Loop-Helix transcription factors"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden Basic-Helix-Loop-Helix transcription factors.
1. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors
Sammanfattning : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. LÄS MER
2. Regulation and functions of basic helix-loop-helix transcription factors in neuroblastoma cells
Sammanfattning : Neuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. LÄS MER
3. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control
Sammanfattning : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. LÄS MER
4. Transcriptional regulation and effects on differentiation by LMO proteins and the basic helix-loop-helix factors TAL1 and HEN1
Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most widespread type of cancer, as well as the most frequent leukemia in children. Malignant ALL cells originate from normal T lymphocytes or B cells that are blocked at immature stages of differentiation. LÄS MER
5. Transcriptional networks in neuroblastoma and breast cancer
Sammanfattning : Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. LÄS MER