Sökning: "FGFR3"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet FGFR3.

  1. 1. MOLECULAR PROFILING OF UROTHELIAL CARCINOMA

    Författare :David Lindgren; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetik; Urology; nephrology; Urologi; nefrologi; Clinical genetics; Klinisk genetik; cytogenetics; Genetics; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; TP53; FGFR3; gene expression profiling; microarray; bladder cancer; urothelial carcinoma; Genetik;

    Sammanfattning : The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study dysregulated transcriptional networks in a large cohort of UCs. LÄS MER

  3. 2. Clinical and genetic investigation of hypochondroplasia and dyschondrosteosis

    Författare :Giedre Grigelioniene; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Linear body growth is a multifactorial trait influenced by many environmental and intrinsic factors. Among the intrinsic determinants of body height, genetic and endocrine factors are considered to be the most important. LÄS MER

  4. 3. Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea

    Författare :Katherine B Szarama; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells in the mammalian hearing organ, the cochlea, develop a specialized patterning and cellular architecture necessary for hearing function. Cytoskeletal components, such as actin and microtubules, maintain the material and mechanical properties of these cells. LÄS MER

  5. 4. Recurrent Non-Muscle-Invasive Bladder Cancer

    Författare :Sigurdur Gudjonsson; Urologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; early instillation; biopsies; biomarkers; recurrence; bladder cancer; non-muscle-invasive; tissue microarray; gene-expression;

    Sammanfattning : A characteristic feature of non-muscle-invasive bladder cancer (NMIBC) is the high risk of recurrent disease after primary treatment. Although only a minority of cases eventually progress to a life-threatening muscle-invasive tumour, it is necessary to conduct long-term follow-up with repeated cystoscopies. LÄS MER

  7. 5. CANCER-RELATED GENE REGULATION MECHANISMS

    Författare :Srinivas Veerla; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer is a disease characterized by deregulation of cellular functions. The means by which these changes occur may differ among cancer types. However, common to all cancers are that they have changed the genetic programs that determine their characteristics. Genetic programs are mainly regulated by the action of transcription factors. LÄS MER