Sökning: "Asthma phenotypes"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden Asthma phenotypes.

  1. 1. Extracellular Matrix Alterations in Patients with Different Phenotypes of Asthma

    Författare :Maria Weitoft; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Extraceullar matrix; Proteoglycan; Collagen; Hyaluronan; Fibrocyte; Mast cell; Nitric oxide;

    Sammanfattning : AbstractAsthma is a chronic disease that affects approximately 300 million people worldwide, and the prevalence is increasing. It has become clear that asthma is a highly heterogeneous disease, with overlapping symptoms but with diverse immunopathology and clinical phenotypes. LÄS MER

  3. 2. Characterization of fibroblast phenotypes in human airway remodeling

    Författare :Kristoffer Larsen; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; remodeling; General biomedical sciences; Biomedicinska vetenskaper allmänt ; fibrocytes; proteoglycans; Asthma; fibroblasts;

    Sammanfattning : Wound healing that precedes scar formation may be unbalanced under pathological conditions leading to structural changes of the tissue. At the moment, the mechanisms behind this unbalance are unclear. When these changes occur in internal organs such as the lung, they may result in organ dysfunction with fatal consequences for the patient. LÄS MER

  4. 3. Asthma in West Sweden - a translational study from epidemiology to proteomics

    Författare :Linda Ekerljung; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; asthma; epidemiology; proteomics; respiratory symptoms; medication;

    Sammanfattning : Asthma has been increasing in prevalence and morbidity, however it is unclear if the increase continues. Asthma has long been regarded as a single disease entity, but is now recognised as a heterogenic disease with different phenotypes. LÄS MER

  5. 4. Study of biomarkers for improved diagnosis and therapy monitoring in young asthmatics

    Författare :Nikolaos Tsolakis; Kjell Alving; Lennart Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma phenotypes; IgE sensitization; atopy; cat allergen components; exhaled NO; airway hyper-responsiveness; lung function; asthma-related quality of life.;

    Sammanfattning : Background: Type-2 asthma is often related to atopy and is characterized by elevated type-2 biomarkers. However, less is known about the pathophysiology of non-type 2 asthma, factors associated therewith, and the stability of different asthma phenotypes over time. LÄS MER

  7. 5. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes

    Författare :Per Gyllfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :>asthma; aspirin intolerance; leukotrienes; leukotriene D4 responsiveness; methacholine responsiveness; exhaled nitric oxide;

    Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER