Sökning: "Antivirals"

Visar resultat 16 - 20 av 27 avhandlingar innehållade ordet Antivirals.

  1. 16. Harnessing the immunoregulatory capacity of single-stranded oligonucleotides to modulate innate immunity

    Författare :Aleksandra Dondalska; Anna-Lena Spetz; Jenny Hallgren Martinsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; single-stranded oligonucleotides; Toll-like receptors; influenza; respiratory syncytial virus; dendritic cell; mast cell; virus infection; inflammation; itch; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : As the first line of defense, the innate immune system is exceptionally efficacious against invading pathogens but must be tightly regulated to avoid immune-related pathogenesis. Accordingly, the innate immune system recognizes highly conserved components associated with infections and damaged cells using a limited number of pattern-recognition receptors (PRRs), which are differentially expressed across cell types. LÄS MER

  3. 17. SARS-CoV-2 viremia in patients hospitalised for COVID-19

    Författare :Karl Hagman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : More than 6.6 million people have died from Covid-19 since the SARS-CoV-2 outbreak started in Wuhan, China, late 2019. The spread of the novel virus necessitated knowledge on how to manage this new disease. LÄS MER

  4. 18. Tailored conjugates of N-acetylneuraminic acid and small molecules that block virus cell attachment and entry

    Författare :Emil Johansson; Mikael Elofsson; Niklas Arnberg; Geert-Jan Boons; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-acetylneuraminic acid; Neu5Ac; sialic acid; multivalency; Coxsackievirus A24v CVA24v ; Human adenovirus D37; D36; D26; HAdV-D37; HAdV-D26; HAdV-D36 ; 4-O-alkyl Neu5Ac; cryo-EM; branched pleconaril probes; conjunctivitis; organisk kemi; Organic Chemistry;

    Sammanfattning : Viruses are obligate intracellular parasites, unable to replicate without exploiting machinery andmaterials from host cells. Pandemics of viral diseases have had large impacts on human socieities and are continued threats to global health. LÄS MER

  5. 19. Cellular receptors for species B adenoviruses

    Författare :Marko Marttila; Niklas Arnberg; Göran Wadell; Tomas Bergström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; CD46; CD80; CD86; Species B; Receptor; Internalization; Infection; Tropism; Virology; Virologi;

    Sammanfattning : Adenoviruses belong to the most common human pathogens. The severity of infection varies greatly, from subclinical to lethal, depending on the virus type and immune status of the infected host. The 51 known human adenovirus serotypes are divided into six species (A-F) based on characteristics such as tropism. LÄS MER

  7. 20. Severe viral respiratory tract infections in children

    Författare :Samuel Arthur Rhedin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Respiratory tract infections (RTIs) are estimated to cause 703.000 deaths annually in children below five years. The majority of RTIs in children are caused by viruses, yet the number of antivirals approved for treatment of these infections is very limited. LÄS MER