Sökning: "Antivirals"

Visar resultat 21 - 25 av 27 avhandlingar innehållade ordet Antivirals.

  1. 21. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention

    Författare :Kicki Bergefall; Göteborgs universitet; []
    Nyckelord :HSV; glycoproteins; glycosaminoglycans; virus receptor; antiviral drugs;

    Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER

  3. 22. Crimean-Congo hemorrhagic fever virus : interactions with host cell structures in viral replication

    Författare :Melinda Simon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Crimean-Congo hemorrhagic fever virus (CCHFV) is a human pathogen, and was first associated with its corresponding disease during an outbreak in the mid 1940s. At that time, outbreaks were mainly restricted to the former Soviet Union, Africa and Asia, but lately disease incidents have markedly risen and CCHFV is now also endemic in several countries in the Middle East and Europe. LÄS MER

  4. 23. HIV/HCV co-infection in Sweden : epidemiology, HCV treatment and the importance of IL28B gene polymorphism

    Författare :Jenny Stenkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Liver disease, mainly due to hepatitis C virus (HCV) infection, is a leading cause of death in HIV positive patients with access to antiretroviral therapy (ART). HCV treatment, which can prevent long-term complications of HCV infection, is available. Despite this, only a minority of HIV/HCV co-infected patients initiate HCV treatment. LÄS MER

  5. 24. Alphavirus-host interactions : how to unravel the proviral activity of G3BP

    Författare :Benjamin Götte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically distinguished into Old World and New World alphaviruses. LÄS MER

  7. 25. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus

    Författare :Koushikul Islam; Clas Ahlm; Magnus Evander; Anna K. Överby; Johan Neyts; Umeå universitet; []
    Nyckelord :Rift Valley fever virus; antiviral; assay development; screening; drug discovery;

    Sammanfattning : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. LÄS MER