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Visar resultat 1 - 5 av 31 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Neoadjuvant chemotherapy in muscle-invasive urinary bladder cancer : studies on treatment response, tumor draining lymph nodes and blood transfusion

    Författare :Robert Rosenblatt; Amir Sherif; Ola Winqvist; Per Marits; Ralph Peeker; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bladder cancer; neoadjuvant chemotherapy; tumor downstaging; sentinel nodes; blood transfusion; Urology; kirurgi; särskilt urologi; Medicine; medicin;

    Sammanfattning : Muscle-invasive urinary bladder cancer is a deadly disease. Mortality rates remained unchanged for decades despite radical surgery.After several randomized trials, we today know that cisplatin based chemotherapy given prior to cystectomy, improves survival for every tenth patient. LÄS MER

  3. 2. Sentinel Node Biopsy for Breast Cancer : Aspects and evolution

    Författare :Andreas Karakatsanis; Fredrik Wärnberg; Peter Stålberg; Helena Olofsson; Lisa Rydén; Uppsala universitet; []
    Nyckelord :Breast Cancer; Sentinel Node Biopsy; Superparamagnetic Iron Oxide;

    Sammanfattning : Sentinel Node Biopsy (SNB) in clinical practice was pivotal to the shaping of modern diagnosis, staging and treatment of patients with breast cancer. The use of radioisotope (RI) and blue dye (BD) has led to high detection rates with low false negatives, but delivery-of-care limitations connected to these tracers as well as the need for methods addressing new clinical conundrums delineates the urge for new tracers with comparable performance, easier logistics and, ideally expanded implementations. LÄS MER

  4. 3. Detecting prostate cancer metastases - PET/CT and the sentinel node technique

    Författare :Henrik Kjölhede; Malmö Urologisk cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Metastases; PET CT; Choline; Fluoride; Sentinel lymph nodes;

    Sammanfattning : Prostate cancer is one of the most common malignancies. Its treatment is highly dependent on the presence or absence of metastases. The available invasive and non-invasive modalities for detecting metastases are imperfect. LÄS MER

  5. 4. Superparamagnetic iron oxide nanoparticles (SPIONs) as a multimodality imaging probe for sentinel nodes : Design and Preclinical Evaluation

    Författare :Renata Madru; Lund Medicinsk strålningsfysik; []
    Nyckelord :iron oxide; nanoparticles; SPIONs; PET-MRI; SPECT-MRI; SPECT-MRI- optical imaging; sentinel lymph node; SNL;

    Sammanfattning : Breast cancer and malignant melanoma disseminate through the lymphatic system and the first metastases arise in one or two regional, sentinel lymph nodes (SLNs) draining the primary tumour site. Therefore, identification and characterization of the SLNs is of major importance for cancer staging and for choice of therapy in patients. LÄS MER

  7. 5. Sentinel node based immunotherapy of cancer

    Författare :Mona Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor draining lymph node, the sentinel node, is regarded as a valuable station for staging and evaluating prognoses for patients with cancer. The object of this thesis was to investigate the immune response against solid cancers and to explore the sentinel node as a source of naturally occurring tumor reactive lymphocytes, for further activation and expansion in vitro for the purpose of immunotherapy. LÄS MER