Sökning: "platelet aggregation"

Visar resultat 16 - 20 av 82 avhandlingar innehållade orden platelet aggregation.

  1. 16. Biophysical studies of cell membrane receptors for the growth factors PDGP and EGF : Aspects on lateral and aggregation

    Författare :Pia Ljungquist-Höddelius; Carl-Henrik Heldin; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : When extracellular growth factors bind to their specific cell surface receptors, they elicit a cascade of biochemical events, including tyrosine kinase-mediated phosphorylation and changes in intracellular free ca2+, leading to cell differentiation and proliferation. However, direct effects of ligand-binding on the receptors are poorly understood. LÄS MER

  3. 17. Formation and Relevance of Platelet Subpopulations

    Författare :Anna Södergren; Sofia Ramström; Karin Öllinger; Riitta Lassila; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Platelets are important players in the hemostatic system, acting as guardians of vessel integrity. When they come across a breach in the vessel wall, they quickly adhere to the damaged surface, secrete activating and adhesive compounds from their secretory granules, recruit additional platelets into a growing platelet plug and support the action of the coagulation system. LÄS MER

  4. 18. The role of platelet thrombin receptors PAR1 and PAR4 in platelet activation

    Författare :Karin Vretenbrant Öberg; Tomas Lindahl; Sofia Ramström; Johan Heemskerk; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Platelets play a pivotal role in coagulation and haemostasis. Their most prominent task is to seal damaged blood vessels by the formation of a platelet plug at the damaged area. Once the injury is covered, platelets retract the coagulum to close the wound and allow the blood to flow freely in the vessel. LÄS MER

  5. 19. Effects of high glucose on platelet activation

    Författare :Masoud Razmara; Karolinska Institutet; Karolinska Institutet; Karolinska institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular mortality and morbidity, due to diabetic angiopathy. Hyperglycaemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated the mechanisms underlying hyperglycaemia-induced platelet hyperreactivity and its impact in diabetic patients. LÄS MER

  7. 20. Platelet function in polycythemia vera : studies of agonist and cytokine induced platelet activation

    Författare :Katarina Le Blanc; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycythemia vera (PV) is a malignant myeloproliferative disorder characterized by an increased red cell mass and most often accompanied by leukocytosis and thrombocytosis. The pathogenic mechanisms behind PV are still largely unknown. LÄS MER