Sökning: "fitness landscape"

Visar resultat 21 - 23 av 23 avhandlingar innehållade orden fitness landscape.

  1. 21. High-resolution phenotypic profiling of a eukaryotic ribosome

    Författare :Jonathan Esguerra; Göteborgs universitet; []
    Nyckelord :ribosome; ribosomal protein genes; box C D snoRNA; box H ACA snoRNA; 2’-O-ribose methylation; pseudouridylation; high-resolution phenotypic profiling; chemogenetic profiling; Saccharomyces cerevisiae; rRNA modification;

    Sammanfattning : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. LÄS MER

  3. 22. A Complex Adaptive System Approach on Logistics - Implications of adopting a complexity perspective

    Författare :Fredrik Nilsson; Förpackningslogistik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; logistics systems; logistics; paradigm; epistemology; complex adaptive systems; complexity theory;

    Sammanfattning : The quest of developing the logistics discipline, with a more theoretical foundation, is something several authors have emphasized and called for. Today one could argue that most of the research on logistics has a strong connection to the positivistic paradigm where there is a great emphasis on prediction, rationality and control in the solutions produced. LÄS MER

  4. 23. Strategies to optimize natural killer cell functions in the tumor microenvironment

    Författare :Katharina Helene Susek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer (NK) cell-based therapies are employed in early phase clinical trials. LÄS MER