Sökning: "pseudouridylation"
Hittade 4 avhandlingar innehållade ordet pseudouridylation.
1. High-resolution phenotypic profiling of a eukaryotic ribosome
Sammanfattning : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. LÄS MER
2. An RNA story, from chromatin to protein
Sammanfattning : RNA functions expand well over just coding for protein effectors. Non-coding RNAs oversee translation, RNA processing, and spatial organization of the cellular space, therefore participating in the regulation of almost any cellular process. To add a further layer of complexity, both coding and non-coding RNAs are extensively modified. LÄS MER
3. RNA modifications and post-transcriptional control in cancer and stem cells
Sammanfattning : Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. LÄS MER
4. RNA-binding proteins in transcription and genome integrity
Sammanfattning : For decades, it was believed that RNA was merely an intermediate step between DNA and protein effectors. It is now appreciated that RNA is an extremely versatile molecule that affects almost every aspect inside a cell. LÄS MER
