Sökning: "TP53 mutation"

Visar resultat 26 - 30 av 40 avhandlingar innehållade orden TP53 mutation.

  1. 26. Genetic and molecular characterization of follicular thyroid tumors : diagnostic and prognostic aspects

    Författare :Johan Paulsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and it sometimes metastasize to lungs and bone. A substantial subset of these tumors lacks an identified driver event and no well-established prognostic and diagnostic markers exist. LÄS MER

  3. 27. Blood- and tumor-based analyses for improved prognostics in lung cancer

    Författare :Sofi Isaksson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Lung cancer is a common cancer type associated with poor prognosis. Even in the group of patients with earlystage tumors, for which curative treatment is possible, lung cancer recurrence is frequent. LÄS MER

  4. 28. A genetic study on familial breast cancer predisposing genes

    Författare :Liping Luo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer is the most common malignant disease among women in the western world and 10% of all breast cancer is assumed to constitute hereditary cases. Two major genes, BRCA1 and BRCA2, can only explain a fraction of familial breast cancer. The ATM carriers have high risk of developing breast cancer. LÄS MER

  5. 29. Different genetic pathways involved in colorectal cancer

    Författare :Sima Salahshor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is one of the three leading causes of cancer mortality worldwide with an incidence of approximately one million cases and a mortality of 500 000 annually. Identification of different pathways involved in tumorigenesis of both familial and sporadic colorectal cancer may led to a major breakthrough in the prevention of this potentially curable disease. LÄS MER

  7. 30. PDGFB and P53 in brain tumorigenesis

    Författare :Sanna-Maria Hede; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glioblastoma is the most common, and malignant form of brain tumor. It is characterized by a rapid growth and diffuse spread to surrounding brain tissue. The cell of origin is still not known, but experimental data suggest an origin from a glial precursor or neural stem cell. LÄS MER