Sökning: "Johan Paulsson"

Hittade 5 avhandlingar innehållade orden Johan Paulsson.

  1. 1. Genetic and molecular characterization of follicular thyroid tumors : diagnostic and prognostic aspects

    Författare :Johan Paulsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and it sometimes metastasize to lungs and bone. A substantial subset of these tumors lacks an identified driver event and no well-established prognostic and diagnostic markers exist. LÄS MER

  3. 2. The stochastic nature of intracellular control circuits

    Författare :Johan Paulsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Stochastic; mesoscopic; noise; gene; plasmid; metabolic; regulation; control; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Chemical reactions are probabilistic by nature, causing random fluctuations inconcentrations to emerge spontaneously. In conventional (macroscopic) kinetics this internal noise is ignored under the assumption that average copy numbers are so high that fluctuations are negligible in comparison. LÄS MER

  4. 3. Proislet Amyloid Polypeptide (proIAPP) : Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes

    Författare :Johan F. Paulsson; Gunilla Westermark; Christer Betsholtz; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biosynthesis amyloid; Genetics amyloid; Metabolism amyloid; Islets of Langerhans; Proprotein convertases; Posttranslation protein processing; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Amyloid is defined as extracellular protein aggregates with a characteristic fibrillar ultra-structure, Congo red affinity and a unique x-ray diffraction pattern. At present, 25 different human amyloid fibril proteins have been identified, and amyloid aggregation is associated with pathological manifestations such as Alzheimer’s disease, spongiform encephalopathy and type 2 diabetes. LÄS MER

  5. 4. Bridge Monitoring to Allow for Reliable Dynamic FE Modelling : A Case Study of the New Årsta Railway Bridge

    Författare :Johan Wiberg; Håkan Sundquist; Raid Karoumi; Björn Paulsson; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; bridge monitoring; FE modelling; signal analysis; torsion; warping; modulus of elasticity; natural frequency; damping; finite differences; Civil engineering and architecture; Samhällsbyggnadsteknik och arkitektur;

    Sammanfattning : Today’s bridge design work in many cases demands a trustworthy dynamic analysis instead of using the traditional dynamic amplification factors. In this thesis a reliable 3D Bernoulli-Euler beam finite element model of the New Årsta Railway Bridge was prepared for thorough dynamic analysis using in situ bridge monitoring for correlation. LÄS MER

  7. 5. Onaturlig födelse : Johan von Hoorn och det obstetriska dilemmat 1680–1730

    Författare :Tove Paulsson Holmberg; Avdelningen för idé- och lärdomshistoria; []
    Nyckelord :HUMANIORA; HUMANITIES; HUMANIORA; HUMANITIES;

    Sammanfattning : .... LÄS MER