Sökning: "TP53 mutation"
Visar resultat 11 - 15 av 40 avhandlingar innehållade orden TP53 mutation.
11. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer
Sammanfattning : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. LÄS MER
12. New Insights in Adrenal Tumourigenesis
Sammanfattning : Unilateral cortisol producing adenoma (CPA) is the most common cause of ACTH-independent Cushing’s syndrome and is surgically curable. On the other hand, adrenocortical carcinomas (ACCs) are rare and aggressive tumours. LÄS MER
13. TP53 mutations in myelodysplastic syndromes with deletion of 5q
Sammanfattning : The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia(s) and increased risk of progression to acute myeloid leukemia (AML). International Prognostic Scoring system (IPSS) Low- or Intermediate (INT)-1 risk MDS with a deletion of 5q (del5q) were considered to have an indolent course and a low risk for progression to AML as compared to other MDS subtypes. LÄS MER
14. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
Sammanfattning : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. LÄS MER
15. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
Sammanfattning : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. LÄS MER