Sökning: "Plasmodium"

Visar resultat 41 - 45 av 148 avhandlingar innehållade ordet Plasmodium.

  1. 41. Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance

    Författare :Maria Isabel Mendes Veiga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development and spread of drug resistance among malaria parasites. LÄS MER

  3. 42. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    Författare :Joel Tärning; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Sammanfattning : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. LÄS MER

  4. 43. Binding Free Energy Calculations on Ligand-Receptor Complexes Applied to Malarial Protease Inhibitors

    Författare :Martin Nervall; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Nyckelord :Molecular biology; Plasmodium falciparum; plasmepsins; linear interaction energy; docking; HIV1 reverse trancriptase; Molekylärbiologi;

    Sammanfattning : Malaria is a widespread disease caused by parasites of the genus Plasmodium. Each year 500 million clinical cases are reported resulting in over one million casualties. The most lethal species, P. falciparum, accounts for ~90% of the fatal cases and has developed resistance to chloroquine. LÄS MER

  5. 44. Virulence in Plasmodium falciparum malaria : mechanisms of PfEMP1-mediated rosetting

    Författare :Davide Angeletti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration and hence microvascular obstruction is associated with virulence of the parasite. LÄS MER

  7. 45. Antigens and antibodies involved in humoral immunity to plasmodium falciparum

    Författare :Mats Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria plasmodiidae cause more death and disease than any other known human pathogen. The parasite still threatens half of the world population {2.5 billion) and 300 million people are considered to become infected every year. LÄS MER