Sökning: "FTICR-MS"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet FTICR-MS.

1. 1. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

   Författare :Joel Tärning; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

   Sammanfattning : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. LÄS MER

3. 2. Analysis of Complex Biological Samples using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

   Författare :Margareta Ramström; Jonas Bergquist; Per Håkansson; Karin Markides; Carol Robinson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; mass spectrometry; liquid chromatography; protein; proteomics; peptide; Fourier transform ion cyclotron resonance mass spectrometry; cerebrospinal fluid; amyotrophic lateral sclerosis; electrospray ionization; electron capture dissociation; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Studies of protein and peptide expression are vital in order to understand complex biological systems. As demonstrated in this thesis, on-line packed capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS) is a useful analytical tool for such studies. LÄS MER

4. 3. Integrated Micro-Analytical Tools for Life Science

   Författare :Sara Bergström; Karin Markides; Marit Andersson; Marja-Liisa Reikkola; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Microdialysis; Multidimensional separation; Liquid chromatography LC ; Capillary electrophoresis CE ; Electrospray ionisation ESI ; Mass spectrometry MS ; Microchip device; Free drug concentration; Screening of microdialysates; Pattern recognition; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Advances in life science require knowledge of active molecules in complex biological systems. These molecules are often only present for a certain time and at limited concentrations. LÄS MER

5. 4. Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites

   Författare :Adnan Halim; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycobiology; Glycoproteomics; Mass Spectrometry;

   Sammanfattning : Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- and O-linked glycosylations is becoming increasingly important. However, current mass spectrometry-based technologies, i.e. LÄS MER

7. 5. Characterisation of natural dissolved organic matter with liquid chromatography and high resolution mass spectrometry

   Författare :Claudia Patriarca; Jonas Bergquist; Lars Tranvik; Per J.R. Sjöberg; Jeffrey A. Hawkes; Norbert Hertkorn; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquatic carbon cycle; dissolved organic matter; DOM; high resolution mass spectrometry; online liquid chromatography; organic matter characterization; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : Dissolved organic matter (DOM) is one of the most heterogeneous and complex mixture on Earth. DOM plays a crucial role in biogeochemical processes on the global scale and it is essential to sustain and regulate the biological processes in aquatic ecosystems. LÄS MER