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1. 1. Angiostatic mechanisms of endogenous angiogenesis inhibitors

   Författare :Niina Veitonmäki; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Angiogenesis; tumor growth; angiostatin; K 1 - 5; adiponectin; hTERT; p16;

   Sammanfattning : Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor nearly 10 years ago. The structure of angiostatin consists of the first three/four kringle (K1-3/K1-4) domains of plasminogen. LÄS MER