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1. 1. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

   Författare :Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. LÄS MER