Sökning: "Daniel Henry Sven Edgar"

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1. 1. Molecular mechanisms of aging in MTDNA mutator mice

   Författare :Daniel Henry Sven Edgar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mitochondria are intensely studied in the field of aging. mtDNA mutator mice have a proofreading deficiency in the mitochondrial DNA polymerase POLG, which causes a large amount of point mutations to be accumulated in mitochondrial DNA. These mice have mitochondrial dysfunction and experience a range of premature aging phenotypes. LÄS MER