Sökning: "urocortin 3"

Hittade 3 avhandlingar innehållade orden urocortin 3.

  1. 1. Somatosensory Circuits in the Central Nervous System

    Författare :Hannah M. Weman; Malin C. Lagerström; Sarah E. Ross; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycine receptor alpha 3; urocortin 3; vesicular monoaminergic transporter 2; nociception; pruriception; spinal cord; somatosensory cortex; DREADD; rabies tracing; transcriptomics; Neuroscience; Neurovetenskap;

    Sammanfattning : Spinal glycinergic neurons prevent spontaneous sensations of pain and itch, and development of persistent pain and itch conditions. The glycine receptor alpha 3 subunit (GLRA3) is suggested to be involved in certain inflammatory models, but not in acute nociception. LÄS MER

  3. 2. Urocortins in the zebrafish brain and redox regulation of embryonic development through glutaredoxins

    Författare :Lars Bräutigam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cellular redox state is a central regulator of embryonic development. Redox homeostasis and thiol redox signaling are modulated through glutaredoxins (Grxs), glutathione dependent thiol-disulfide oxidoreductases. Grxs can reduce protein disulfides and protein-glutathione mixed disulfides (de-glutathionylation) via distinct reaction mechanisms. LÄS MER

  4. 3. Modern roles for an ancient system. Intracellular Complement in the regulation of β cell function

    Författare :Ewelina Golec; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; Diabetes mellitus; Insulin secretion; CD59; C3; Isoforms; SNARE proteins;

    Sammanfattning : Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. LÄS MER