Sökning: "CD59"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet CD59.

1. 1. Membrane rafts and its GPI anchored complement inhibitors regulate insulin secretion

   Författare :Vini Nagaraj; Diabetes - öpatofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Membrane rafts; basal insulin secretion; regulated insulin secretion; CD59; CD55; SNARE proteins; insulin; pancreatic beta cells.;

   Sammanfattning : Type 2 diabetic patients usually exhibit an abnormal lipid profile. One such lipid that is constantly elevated in T2D is cholesterol. At the cellular level, cholesterol aids in tight packing of sphingolipids in certain regions of the plasma membrane and these specialized regions are termed ‘membrane rafts’, which act as signalling hubs. LÄS MER

3. 2. Prostasome Modulation of Blood Cascade System and Phosphoprotein Reactions with Focus on Prostate Cancer

   Författare :Adil Abdelgadir Babiker; Kristina Nilsson Ekdahl; Michael Wilson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; ATPase; CD59; Complement; DU145; Extracellular phosphorylation; LNCaP; PC-3; Prostasomes; Prostate cancer; Protein kinases; Tissue factor; Immunologi; Immunology; Immunologi;

   Sammanfattning : Prostasomes are extracellularly occurring submicron, membrane-surrounded organelles produced by the epithelial cells of the prostate and present in semen. Their precise physiological role is not known, although some of their properties assign them to important physiological and patho-physiological functions. LÄS MER

4. 3. Modern roles for an ancient system. Intracellular Complement in the regulation of β cell function

   Författare :Ewelina Golec; Malmö Proteinkemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; Diabetes mellitus; Insulin secretion; CD59; C3; Isoforms; SNARE proteins;

   Sammanfattning : Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. LÄS MER

5. 4. Congenital Dyserythropoietic Anemia type III (CDA III) : diagnostics, genetics and morbidity

   Författare :Maria Liljeholm; Anders Wahlin; Richard Rosenquist Brandell; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; congenital dyserythropoietic anemia; KIF23; hereditary hemochromatosis; iron overload; flow cytometry;

   Sammanfattning : The Congenital Dyserythropoietic Anemias (CDA) are rare hereditary hemolytic disorders with large bi- to multi-nucleated erythroblasts in the bone marrow. Hemolysis is negative in a direct antiglobulin test (DAT). Based on morphology and clinical picture, three major forms of CDAs, type I, II, and III have been defined. LÄS MER

7. 5. Immunological aspects of papillary thyroid carcinoma

   Författare :Steven D. Lucas; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Papillary thyroid carcinoma; immunology; tumor antigens; RET proto-oncogene; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Sammanfattning : Papillary thyroid carcinoma (PTC) is a puzzling disease. Although approximately 70% of patients with PTC have regional lymph node metastases at initial surgery, the long term survival is over 95%. LÄS MER