Sökning: "taxol"
Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet taxol.
1. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics
Sammanfattning : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. LÄS MER
2. A Novel Rearrangement of Allyl Benzyl Ethers and Aspects on the Glyoxylate Ene Reaction
Sammanfattning : This thesis describes an improvement of the glyoxylate ene reaction by using siamyl glyoxaylate and a development of the novel rearrangement of allyl benzyl ethers. The glyoxylate ene reaction was used as a key reaction in a 8-step synthesis of a Taxol A-ring building block. LÄS MER
3. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives
Sammanfattning : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. LÄS MER
4. High resolution genomic tools for the discovery of protein function in mammalian cells
Sammanfattning : The work described in this thesis emphasizes the development of cell-based strategies with increased throughput design that enable rapid biological discovery through direct investigation of protein function. Each of the works represented in this thesis are unified by the common premise that genetic perturbations, through loss or gain-of-function, in cell-based models may serve as an entry point for assigning biological roles to uncharacterized genes and their gene products. LÄS MER
5. Design, synthesis and evaluation of spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics
Sammanfattning : Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. LÄS MER