Sökning: "subtelomeric regions"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden subtelomeric regions.
1. Genomic and transcripto variation in blood stage Plasmodium falciparum
Sammanfattning : Malaria research has entered a postgenomic era since October 2002, when the complete genomic sequence of Plasmodium falciparum strain 3D7 was published. A massive amount of information generated by the P. falciparum genome project has facilitated the development of many novel platforms for profiling different levels of biological aspects. LÄS MER
2. Gene dose imbalances in children with mental retardation
Sammanfattning : Submicroscopic chromosome aberrations can cause mental retardation (MR), congenital malformations and miscarriage. It is difficult to estimate the contribution of cytogenetic abnormalities to MR because of relatively low detection sensitivity of conventional cytogenetic methods used in the diagnostic setting. LÄS MER
3. Cryptic chromosome abnormalities in idiopathic mental retardation
Sammanfattning : Mental retardation is a common disorder, affecting 1-3% of the population. In spite of improved diagnostic tools, the etiology can still not be established in half of the cases. Several lines of evidence indicate a genetic origin in a significant number of individuals with idiopathic mental retardation. LÄS MER
4. Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization
Sammanfattning : Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence accessibility of DNA elements. LÄS MER
5. Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe
Sammanfattning : The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related events to occur, the chromatin needs to be modified by chromatin remodelling or, by reversible post-translational modifications. LÄS MER