Sökning: "statins"
Visar resultat 1 - 5 av 92 avhandlingar innehållade ordet statins.
1. Statins, HMGCR and Breast Cancer
Sammanfattning : .... LÄS MER
2. Power of the Pill : Views about Cardiovascular Risk and the Risk-reducing Effect of Statins
Sammanfattning : Medical treatments with statins are prescribed to patients with increased risk of cardiovascular events. The benefits from statin treatment are well documented in clinical trials, but long-term adherence in patients is low, indicating that patients have an uncertainty about the necessity and benefits of treatment. LÄS MER
3. Statins, Lipids, and Mutations: Consequences for the Heart and Immune System
Sammanfattning : CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary function. The first step in this process is called prenylation, which is the covalent attachment of a lipid, either a 15-carbon farnesyl or a 20-carbon geranylgeranyl lipid, to the carboxyl-terminal cysteine residue by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase type I (GGTase-I), respectively. LÄS MER
4. Pharmacoepidemiology of Antibiotics, Weak Opioids and Statins with Special Reference to Socioeconomic Aspects - an Ecological Approach
Sammanfattning : The influence of socioeconomic factors on drug utilisation has been studied by pharmacoepidemiological analyses involving 1) drugs that are used to cure disease, such as antibiotics, 2) drugs that are used to alleviate symptoms, such as weak opioids, and 3) drugs that are used to prevent disease, such as statins. In a large Swedish city (Malmö), the utilisation of four major drug groups (ATC-groups A = alimentation, C = circulation, N = nervous system, and R = respiration) correlated positively with an unfavourable socioeconomic situation, most pronouncedly with group N and least so with group R. LÄS MER
5. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions
Sammanfattning : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. LÄS MER