Sökning: "small molecule screening"

Visar resultat 21 - 25 av 59 avhandlingar innehållade orden small molecule screening.

  1. 21. Exploring the interactome of EF-hand proteins

    Författare :Mikael Bauer; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; EF-hand; calcium; STIM; stromal interaction molecule; secretagogin; Calmodulin; calbindin D28k; protein-protein interactions; zinc; protein array;

    Sammanfattning : EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. LÄS MER

  3. 22. Preclinical Characterization in vivo and in vitro of Novel Agents for Cancer Chemotherapy : Studies on Benomyl, Carbendazim, Cryptolepine and Acriflavine

    Författare :Daniel Laryea; Peter Nygren; Moustapha Hassan; Uppsala universitet; []
    Nyckelord :Benzimidazoles; cryptolepine; acriflavine; cancer; high throughput screening; cytotoxic drug; gene expression;

    Sammanfattning : Preclinical methods for the identification and characterization of molecules for development into new cancer drugs were investigated. Based on repurposing, i.e. LÄS MER

  4. 23. Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

    Författare :Amro Hanora; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; macroporous; Biologically active compounds; Biotechnology; Läkemedelsteknik och relaterad teknik; Pharmaceutical and related technologies; Polymerteknik; biopolymers; Biokemisk teknik; Polymer technology; Makromolekylär kemi; Biochemical technology; Affinity chromatography; Ion exchange chromatography; Expanded bed adsorption chromatography.; Macromolecular chemistry; High through put screening; lactica acids; Endotoxin; Plasmid DNA; Cryogel columns; Bioteknik;

    Sammanfattning : The completion of sequencing of human and other mammalian genomes opens a new era for drug development. New approaches have been proposed for tackling diseases such as development of small molecule therapies based on understanding of human genome and proteome, new proteinous based therapies, where the therapeutic protein can inhibit or modify a certain metabolic pathway or DNA-based therapies delivering a gene into the cell (e. LÄS MER

  5. 24. Targeting of the Myc pathway as a novel approach for cancer therapy

    Författare :Hao Mo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :oncogene; tumor suppressor gene; Myc; cellular screening; small molecules; MYRAs; NSC308848; camptothecin; paclitaxel; apoptosis; transcription; transformation.;

    Sammanfattning : As transcription factors, Myc-family proteins function upstream of signaling pathways and regulate cell proliferation, differentiation, angiogenesis, apoptosis and transformation. Precisely regulated Myc expression is critical for cellular physiology, while perturbations of Myc expression have detrimental consequences to the organism. LÄS MER

  7. 25. Development and Application of Computational Methods in Antitubercular Drug Design : Identification of Novel Inhibitors of Ribonucleotide Reductase

    Författare :Daniel Muthas; Anders Karlén; Anders Hallberg; Johan Gottfries; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

    Sammanfattning : Tuberculosis kills approximately 1.7 million people each year around the world making it one of the most lethal infectious diseases. This thesis concerns the development of two computational tools that can support the early stages of drug discovery, and their use in an anti-tubercular drug discovery program. LÄS MER