Sökning: "sensory neurons"

Visar resultat 16 - 20 av 183 avhandlingar innehållade orden sensory neurons.

  1. 16. Antibody activation of sensory neurons : exploring novel pain mechanisms in rheumatoid arthritis

    Författare :Alex Bersellini Farinotti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain is a worldwide major problem that presents several challenges due to lack of treatment efficacy and/or side effects associated with long-term usage of analgesics. Autoimmune diseases such as rheumatoid arthritis (RA) are often characterized by pain components, which generally poorly respond to drug treatment. LÄS MER

  3. 17. Structure and function of trigeminal primary sensory neurons after peripheral nerve injury

    Författare :Ulf Bongenhielm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ankyrinG; chronic constriction injury; electron microscopy; electrophysiology; hyperexcitability; immunocytochemistry; inferior alveolar nerve; in situ hybridisation; nerve injury; neuroma; SNS PN3; sodium channel; trigeminal ganglion;

    Sammanfattning : Iatrogenic injuries to branches of the trigeminal nerve are common during surgical procedures in the jaws and teeth, and as the repercussion of facial fractures or certain pathologies. A portion of these patients are left with disturbed sensory functions, and some with unpleasant abnormal sensations, including pain. LÄS MER

  4. 18. The effects of neurotrophic substances on primary sensory neurons following peripheral nerve injury

    Författare :Petri Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DRG; dorsal horn; NGF; BDNF; NT-3; substance P; calcitonin gene-related peptide; fluoride-resistant acid phosphatase; carbonic anhydrase; microglia; astroglia;

    Sammanfattning : Sensory impulses from the periphery is transmitted by primary sensory neurons located in dorsal root and cranial nerve ganglia. The primary sensory neurons are phenotypically diverse with regard to their expression of various chemical components. LÄS MER

  5. 19. Pain-related sodium channels in sensory neurons : gene expression during development and after injury

    Författare :Jonas Thun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain that goes on over years as a result of nerve damage is an affliction which disables millions of people worldwide. Chronic injury-induced pain can become severely debilitating and extremely difficult to treat. LÄS MER

  7. 20. An exploration of the mechanisms behind peripheral nerve injury

    Författare :Rebecca Wiberg; Liudmila Novikova; Paul Kingham; Ash Mosahebi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peripheral nerve injury; target organ; spinal motoneurons; primary sensory neurons; degeneration; anatomi; Human Anatomy;

    Sammanfattning : Despite surgical innovation, the sensory and motor outcome after peripheral nerve injury is incomplete. In this thesis, the biological pathways potentially responsible for the poor functional recoveries were investigated in both the distal nerve stump/target organ, spinal motoneurons and dorsal root ganglia (DRG). LÄS MER