Sökning: "round window membrane"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden round window membrane.

1. 1. The Round Window Membrane - Gateway to the Cochlea : A Morphological and Electrophysiological study

   Författare :Leif Nordang; Sten Hellström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otorhinolaryngology; round window membrane; pseudomonas exotoxin; auditory brainstem response; hearing loss; endolymphatic sac; inner ear immunology; glutamate; nitric oxide inhibitor; glucocorticoid.; Otorhinolaryngologi; Otorhinolaryngology; Otorhinolaryngologi; Oto-Rhino-Laryngology; oto-rhino-laryngologi;

   Sammanfattning : Topical treatment of several inner ear diseases through the round window membrane (RWM) might be feasible in the near future. Bacteria toxins, ototoxic drugs and noise trauma seem to harm the inner ear by a common pathway which involves, excessive outflow of the afferent neurotransmitter glutamate and formation of nitric oxide (NO), which can severely damage cells/nerve endings and lead to cell death. LÄS MER

3. 2. Round window membrane and delivery of biologically active agents into the cochlea

   Författare :Amanj Saber; Mats Ulfendahl; Lars Lundman; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet Department of Clinical Neoruscience; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Round window membrane; sodium hyaluronate; chitosan; local cochlear drug delivery and gene delivery; Oto-rhino-laryngologi; Oto-Rhino-Laryngology; Biology; Biologi; Round window membrane; sodium hyaluronate; chitosan; local cochlear drug delivery and gene delivery;

   Sammanfattning : Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue. LÄS MER

4. 3. Topical anesthesia of the tympanic membrane : an experimental animal study

   Författare :Sten-Hermann Schmidt; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Topical anesthesia; middle ear; tympanic membrane; cochlea; collagen fibres; lidocaine; 96 % phenol; Bonain s liquid; auditory brainstem response; ototoxicity; cytocochleogram; scanning electron microscopy; rat; guinea pig;

   Sammanfattning : Myringotomy plays an important role in otological therapy. The procedure requires an efficient anesthesia, which can be obtained without general anesthesia. However, the use of local anesthetics on the tympanic membrane (TM) has been abandoned in many places, as general anesthesia has been readily available. LÄS MER

5. 4. Time-related Aspects of Otoprotection : Experimental Studies in Rat

   Författare :Adnan Lidian; Matti Anniko; Petri Olivius; Uppsala universitet; []
   Nyckelord :sensorineural hearing loss; Edaravone; brain-derived neurotrophic factor; auditory brainstem response; Sprague-Dawley rat; distortion product otoacoustic emission; Pseudomonas aeruginosa exotoxin A.; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

   Sammanfattning : Intratympanic injection of various otoprotectants through the round window membrane (RWM) might become available in the near future as an alternative to the currently available medical and surgical methods used to treat several inner ear diseases. The most common outcome of such diseases is sensorineural hearing loss (SNHL). LÄS MER

7. 5. Middle Ear Cholesteatoma : Surgical Treatment, Follow-up and Hearing Restoration

   Författare :Lennart Edfeldt; Helge Rask-Andersen; Juha Silvola; Uppsala universitet; []
   Nyckelord :Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

   Sammanfattning : Although middle-ear cholesteatoma is a major topic in otological research, its etiology and pathogenesis remain unclear. Pediatric cholesteatoma is considered more aggressive than adult cholesteatoma, as it has a higher rate of growth, is more often infected and exhibits wider extension. LÄS MER