Sökning: "ototoxicity"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet ototoxicity.

  1. 1. Cochlear Ototoxicity : a temporal bone histopathology study

    Författare :Georgios Stamatiou; UK London University College London Ear Institute Faculty of Brain Sciences; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 2. Topical anesthesia of the tympanic membrane : an experimental animal study

    Författare :Sten-Hermann Schmidt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Topical anesthesia; middle ear; tympanic membrane; cochlea; collagen fibres; lidocaine; 96 % phenol; Bonain s liquid; auditory brainstem response; ototoxicity; cytocochleogram; scanning electron microscopy; rat; guinea pig;

    Sammanfattning : Myringotomy plays an important role in otological therapy. The procedure requires an efficient anesthesia, which can be obtained without general anesthesia. However, the use of local anesthetics on the tympanic membrane (TM) has been abandoned in many places, as general anesthesia has been readily available. LÄS MER

  4. 3. Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention

    Författare :Andreas Ekborn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cisplatin; ototoxicity; pharmacokinetics; monohydrated complex of cisplatin; protection;

    Sammanfattning : Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. LÄS MER

  5. 4. Cisplatin : a platinum-containing antineoplastic drug : perspectives on analytical chemistry and prevention of ototoxicity

    Författare :Pernilla Videhult Pierre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cisplatin;

    Sammanfattning : The platinum-containing drug cisplatin plays a key role in the curative and palliative treatment of many solid malignancies. Unfortunately, the treatment can lead to sensorineural hearing loss, which limits the use of the drug. LÄS MER

  7. 5. Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance

    Författare :Evangelia Tserga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are poorly understood. LÄS MER