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Visar resultat 16 - 20 av 212 avhandlingar som matchar ovanstående sökkriterier.
16. Hereditary Nonpolyposis Colorectal Cancer - Molecular Genetics and Biology of Associated Tumors
Sammanfattning : This thesis focuses on one of the most common types of hereditary cancer, hereditary nonpolyposis colorectal cancer (HNPCC). This syndrome is characterized by an autosomal dominant inheritance, an increased risk for several types of cancer (especially cancer of the colorectum, small bowel, endometrium, ovary and urinary tract), early age at diagnosis, and frequent development of multiple primary malignancies. LÄS MER
17. Mitochondrial DNA : analysis of the control region in forensic and population genetic studies
Sammanfattning : .... LÄS MER
18. Studies of polyglutamine repeats and their biology in relation to disease
Sammanfattning : Polyglutamine repeat expansions of the CAG/CTG type frequently lead to disease characterized by progressive neuronal dysfunction. These diseases typically begins in mid-life and result in severe neurodegeneration. To a certain extent they present with similar features and probably share a common mechanism of pathogenesis. LÄS MER
19. Identification and investigations of leucine-rich repeats and immunoglobulin-like domains protein 2 (LRIG2)
Sammanfattning : Receptor tyrosine kinases (RTKs) constitute a family of proteins controlling cell growth and proliferation and whose activities are tightly controlled in normal cells. LRIG1 is a negative regulator of RTK signaling and is a proposed tumor suppressor. The aim of this thesis was to identify and study possible paralogs of LRIG1. LÄS MER
20. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia
Sammanfattning : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. LÄS MER