Sökning: "regulatory element"

Visar resultat 1 - 5 av 119 avhandlingar innehållade orden regulatory element.

  1. 1. Cis-regulatory variation and divergence in Capsella

    Författare :Kim A. Steige; Tanja Slotte; Jeff J. Doyle; Uppsala universitet; []
    Nyckelord :Capsella; Shepherd s Purse; cis-regulatory changes; allele-specific expression; mating system shift; floral evolution; polyploidy; positive selection; purifying selection; transposable elements; small RNA; methylation; transposable element silencing; distribution of fitness effects;

    Sammanfattning : Cis-regulatory changes in e.g. promoters or enhancers that affect the expression of a linked focal gene have long been thought to be important for adaptation. In this thesis, I investigate the selective importance and genomic correlates of cis-regulatory variation and divergence in the genus Capsella, using massively parallel sequencing data. LÄS MER

  3. 2. Elucidation of complex diseases by machine learning

    Författare :Karolina Smolinska Garbulowska; Jan Komorowski; Claes Wadelius; Tuuli Lappalainen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; machine learning; complex disease; multi-omics; regulatory element; gene regulation; transcription factor motif; networks; rough sets; Bioinformatics; Bioinformatik;

    Sammanfattning : Uncovering the interpretability of models for complex health-related problems is a crucial task that is often neglected in machine learning (ML). The amount of available data makes the problem even more complicated. LÄS MER

  4. 3. Assessment of trace element stabilization in soil

    Författare :Jurate Kumpiene; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Waste Science and Technology; Avfallsteknik;

    Sammanfattning : The thesis deals with the remediation of trace element contaminated soil by the chemical stabilization technique. The objective is to complement the knowledge about possibilities of applying the stabilization either (1) as an alternate soil remediation method to excavation and landfilling or (2) for a pre-treatment of contaminated soil before landfilling. LÄS MER

  5. 4. A concrete dam assessment approach using probabilistic non-linear finite element analysis and scale model testing

    Författare :Adrian Ulfberg; Gabriel Sas; Oisik Das; Jaime Gonzalez; Richard Malm; Fredrik Johansson; Marie Westberg Wilde; Leif Lia; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Finite element analysis; Scale model testing; Probabilistic analysis; Byggkonstruktion; Structural Engineering;

    Sammanfattning : Dams are vital infrastructure for society as they provide various services (e.g., flood prevention, storage of byproducts from mining operations, water storage for irrigation and hydropower generation) by the impoundment of liquids. LÄS MER

  7. 5. Regulatory roles of sRNAs in pathogenesis of Vibrio cholerae

    Författare :Dharmesh Sabharwal; Sun Nyunt Wai; Bernt Eric Uhlin; Jörgen Johansson; Cynthia Sharma; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; sRNA; Biofilm; OmpT; RbmC; Vrp; VafA; mikrobiologi; Microbiology;

    Sammanfattning : The Gram-negative pathogen Vibrio cholerae uses variety of regulatory molecules to modulate expression of virulence factors. One important regulatory element of microorganisms is small non-coding RNAs (sRNAs), which control various cell functions such as expression of cell membrane proteins, mRNA decay and riboswitches. LÄS MER