Sökning: "radionuclide molecular imaging"

Visar resultat 6 - 10 av 32 avhandlingar innehållade orden radionuclide molecular imaging.

  1. 6. Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies

    Författare :Diana Spiegelberg; Marika Nestor; Bo Stenerlöw; Johan Lennartson; Theodosia Maina-Nock; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor targeting; radionuclide targeting; HSP90 inhibition; AT13387; radiosensitization; molecular imaging; combination treatment; EGFR; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER

  3. 7. Affibody-Based Molecular Imaging and Targeted Therapy of HER3-Expressing Cancer

    Författare :Sara Sophie Rinne; Anna Orlova; Vladimir Tolmachev; Mohamed Altai; Anzhelika Vorobyeva; Melpomeni Fani; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular Imaging; PET; SPECT; Cancer; Affibody; HER3; Targeted Therapy;

    Sammanfattning : The human epidermal growth factor receptor type 3 (HER3) is overexpressed in different types of cancer and is a known contributor to disease progression and resistance to cancer therapy. This thesis is based on five original articles, which aimed to improve the diagnostic and therapeutic potential of affibody-based agents for management of HER3-expressing cancers. LÄS MER

  4. 8. Development of ADAPT-based tracers for radionuclide molecular imaging of cancer

    Författare :Javad Garousi; Vladimir Tolmachev; Tony Lahoutte; Uppsala universitet; []
    Nyckelord :ADAPT; scaffold protein; albumin-binding domain ABD ; Affinity protein; HER2; radionuclide molecular imaging;

    Sammanfattning : ABD-Derived Affinity Proteins (ADAPTs) is a novel class of small engineered scaffold proteins based on albumin-binding domain (ABD) of streptococcal protein G. High affinity ADAPT  binders against various therapeutic targets can be selected. LÄS MER

  5. 9. Multiparametric MRI for evaluation of tumour treatment response : Studies of 177Lu-octreotate therapy of neuroendocrine tumour

    Författare :Mikael Montelius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Functional imaging; IVIM; MRI; DWI; DCE; histology; 177Lu-octreotate; small intestine neuroendocrine tumour; NET; diffusion; perfusion; semi-quantitative; proteomics; ionizing radiation; biology; imaging biomarker;

    Sammanfattning : Clinical assessment of tumour response to treatment largely relies on estimates of tumour size by, e.g., measuring the largest tumour diameters on magnetic resonance (MR) or computed tomography (CT) images, weeks or months after treatment. LÄS MER

  7. 10. Lutetium-177-octreotate treatment of small intestine neuroendocrine tumors - Radiation biology as basis for optimization

    Författare :Johan Spetz; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Peptide receptor radionuclide therapy; PRRT; somatostatin receptors; SSTR; midgut carcinoid; radiogenomics;

    Sammanfattning : Patients with neuroendocrine tumors (NETs) often have metastatic spread at the time of diagnosis. NETs frequently express somatostatin receptors (SSTR) that can be targeted by radiolabeled somatostatin analogs (e.g. 177Lu-octreotate). LÄS MER