Sökning: "quinolone resistance"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden quinolone resistance.

  1. 1. New antibiotic resistance genes and their diversity

    Författare :Fanny Berglund; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metagenomics; β-lactamases; hidden Markov model; antibiotic resistance; carbapenemases; big data; tetracycline resistance;

    Sammanfattning : Antibiotic resistance is increasing worldwide and is considered a severe threat to public health. Often, antibiotic resistance is caused by antibiotic resistance genes, of which many are hypothesized to have been transferred into human pathogens from environmental bacteria. LÄS MER

  3. 2. Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens

    Författare :Herin Oh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Quinolone; resistance; B. fragilis; P. aeruginosa; topoisomerase; efflux;

    Sammanfattning : Opportunistic pathogens can cause infections in case of structural or functional defects in the host. Examples of Gram-negative opportunists are the Bacteroides fragilis group, anaerobic, non-spore forming rods and the aerobic, non-fermentative rod Pseudomonas aeruginosa. LÄS MER

  4. 3. Identification of novel antibiotic resistance genes through large-scale data analysis

    Författare :Fanny Berglund; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metagenomics; hidden Markov model; carbapenemases; antibiotic resistance; big data; carbapenemases;

    Sammanfattning : Antibiotic resistance is increasing worldwide, and is considered a serious threat to public health by e.g. the World Health Organization. Antibiotic resistance genes are hypothesized to originate from harmless bacteria in and around us, from where they are horizontally transfered into human pathogens. LÄS MER

  5. 4. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa

    Författare :Shah Jalal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :quinolone resistance; P. aeruginosa; PCR; DNA sequencing; mutation; NIRCA; RESA; multidrug efflux; cystic fibrosis;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. In compromised human, it can cause infections in urinary tract, wound and respiratory tract such as pneumonia and progressive lung diseases. LÄS MER

  7. 5. Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae

    Författare :Emma Lindbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neisseria gonorrhoeae; ciprofloxacin; DNA-gyrase; topoisomerase IV; major outer membrane protein;

    Sammanfattning : A few years ago, most strains of Neisseria gonorrhoeae were susceptible to ciprofloxacin, but after introduction as a first line therapy, resistant strains emerged. Ciprofloxacin inhibit two enzymes necessary for DNA replication. LÄS MER